Thermo Fisher Scientific ABCA1 Monoclonal Antibody (6B7A11)
ABCA1 단백질을 인식하는 Mouse IgG2a 단일클론 항체로, Western blot, ICC/IF, Flow cytometry에 적합합니다. Tangier disease 관련 연구에 활용 가능하며, 고순도 Protein G 정제 및 안정적 PBS 버퍼 보존으로 신뢰성 높은 결과를 제공합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:200–1:1,000 |
| Flow Cytometry (Flow) | 1:200–1:400 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 6B7A11 |
| Immunogen | Purified recombinant fragment of human ABCA1 (AA: 2081–2261) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3091347 |
Target Information
Mutations in the ABCA1 gene (ATP-binding cassette transporter 1) have been reported in Tangier disease (TD).
TD is an autosomal recessive disorder characterized by an absence of plasma HDL, cholesterol ester deposition in the reticuloendothelial system, and deviations in cellular lipid trafficking.
ABCA1 mediates the apo-A1–associated export of cholesterol and phospholipids from the cell. It is expressed on the plasma membrane and the Golgi complex, and is regulated by cholesterol flux.
Regulation of the cholesterol flux between HDL and macrophages is competitive between ABCA1 and SR-BI.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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