Thermo Fisher Scientific IRAK-2 Polyclonal Antibody
IRAK-2 단백질을 검출하기 위한 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 IHC에 적합하며, 인간 시료에 반응. 항원 친화 크로마토그래피로 정제된 고품질 항체로 안정적인 신호 검출 제공.
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Thermo Fisher Scientific IRAK-2 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–10 µg/mL |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide derived from internal segment of human IRAK-2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: Breast carcinoma
- Cellular location: Cytoplasmic
Target Information
IRAK2 (interleukin-1 receptor-associated kinase-like 2) binds to the IL-1 type I receptor following IL-1 engagement and triggers intracellular signaling cascades that lead to transcriptional up-regulation and mRNA stabilization.
The pro-inflammatory cytokine IL-1 induces cellular responses through two subunits of its receptor, IL-1 receptor I (IL-1RI) and IL-1 receptor accessory protein (IL-1RAcP).
IL-1 receptor-associated kinase (IRAK) mediates activation of NF-kappa-B, a pivotal transcription factor mediating inflammatory and immune responses.
A novel member in the IRAK/Pelle family, IRAK2, recruits to the subunits of the IL-1R complex after IL-1 binding and leads to NF-kappa-B activation.
IRAKs also associate with Toll-like receptors (TLR), and dominant negative mutants of IRAKs inhibit LPS-induced NF-kappa-B activation.
Members in the IRAK/Pelle family play a central role in IL-1R and TLR-mediated inflammatory responses to cytokine IL-1 and LPS.
IRAK2 is expressed in a variety of human tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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