Thermo Fisher Scientific Caspase 12 Polyclonal Antibody
Caspase-12 단백질을 인식하는 토끼 폴리클로날 항체로, Western blot 및 IHC(P) 분석에 적합합니다. 인간, 생쥐, 랫트 시료에 반응하며, ER 스트레스 관련 세포사멸 연구에 유용합니다. 항원 친화 크로마토그래피로 정제된 고순도 항체입니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide derived from internal sequence of mouse Caspase 12 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C for short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: Brain tissue
- Cellular location: Cytoplasmic
Target Information
Three distinct signaling pathways lead to programmed cell death (apoptosis). The death receptor and mitochondrion pathways are the main routes, involving the key apoptotic proteases caspase-8 and caspase-9, respectively. The endoplasmic reticulum (ER) stress pathway is the third apoptotic pathway, in which caspase-12 is involved.
Caspase-12 is localized to the ER, not to the cytoplasm or mitochondria. It is activated by ER stress, including disruption of ER calcium homeostasis, and mediates ER stress-induced apoptosis. Caspase-12 co-localizes with ER proteins related to Alzheimer’s disease, such as γ-secretase presenilin and β-amyloid precursor protein (APP), and mediates cytotoxicity induced by amyloid-β. Caspase-12 is ubiquitously expressed in mouse tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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