Thermo Fisher Scientific CCDC141 Polyclonal Antibody
CCDC141 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체. Western blot과 IHC에 사용 가능하며, 인간 및 마우스 시료에 반응. 항원 친화 크로마토그래피로 정제되어 높은 특이성과 재현성을 제공. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| Immunohistochemistry (IHC) | 5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | An 18 amino acid peptide near the amino terminus of human CCDC141 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months; for long term storage store at -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11151939 |
Product Specific Information
- Suggested positive control: SK-N-SH cell lysate
- PA5-21169 can be used with blocking peptide PEP-1283
Target Information
Coiled-coil domain-containing protein 141 (CCDC141), also known as CAMDI, is a DISC1-binding protein that associates with myosin II. CCDC141 preferentially binds phosphomyosin II and promotes its accumulation at the centrosome in a DISC1-dependent manner. Knockdown of CCDC141 expression by RNAi causes impaired radial migration and disoriented chromosomes, indicating its essential role in neuronal development through DISC1 and myosin II-mediated centrosome positioning.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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