Thermo Fisher Scientific EAAC1 Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

Product is shipped at room temperature as a lyophilized powder and should be stored at -20°C upon receipt.
Reconstitution: add 50 µL of deionized water.

Target Information

L-glutamate is the major excitatory neurotransmitter in mammalian central nervous systems. To maintain glutamate levels below excitotoxic levels, excess glutamate at excitatory synaptic clefts is removed by ion-coupled glutamate transporters.
Four glutamate transporters have been identified: the sodium-dependent GLAST-1, GLT-1, EAAC-1, and the chloride-dependent EAAT-4.
EAAC-1 is expressed in the CNS and also found in kidney and small intestine. Structural features of glutamate transporters include eight membrane-spanning alpha-helices and a loop-pore structure, unique among secondary transporters.
A second distinctive structural feature is a highly amphipathic membrane-spanning helix that provides a hydrophilic path through the membrane.
Mice with homozygous deletions of the EAAC-1 transporter gene develop dicarboxylic aminoaciduria and display reduced spontaneous locomotor activity, although no neurodegeneration was observed over a period of 12 months.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.