Thermo Fisher Scientific p53 Monoclonal Antibody (OTI7F3), TrueMAB
인간 p53 단백질을 인식하는 Mouse IgG1 단클론 항체로, Western blot과 IHC(Paraffin)에 최적화됨. TrueMAB 형식으로 고순도 친화 크로마토그래피 정제. 세포 스트레스 및 DNA 손상 반응 연구용으로 적합.
- 판매단위
- pk
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Applications
- Western Blot (WB): 1:2,000
- Immunohistochemistry (Paraffin) (IHC (P)): 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI7F3 |
| Immunogen | Full length human recombinant protein of human TP53 produced in SF9 cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The tumor suppressor protein p53 is a sequence-specific transcription factor activated by cellular stress. It mediates cell cycle arrest or apoptosis in response to DNA damage or nutrient deprivation. p53 activation leads to transcription of genes such as p21waf1, involved in G1 or G2/M arrest.
p53 consists of:
- N-terminal transactivation domain
- Central DNA-binding domain
- Oligomerisation domain
- C-terminal regulatory domain
Phosphorylation at Ser15 is crucial for activation and stabilization, while Ser392 phosphorylation correlates with tumor formation. p53 plays roles in preventing proliferation of damaged cells, aging, oxidative stress, and learning/memory processes.
Mutations in the TP53 gene are common in human cancers, leading to loss of tumor suppressor function. Germline mutations are also found in cancer-prone families such as Li-Fraumeni syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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