Thermo Fisher Scientific CD223 (LAG-3) Monoclonal Antibody (3DS223H), Alexa Fluor 700, eBioscience
인간 CD223(LAG-3)을 인식하는 3DS223H 단클론 항체로, Alexa Fluor 700 형광 표지. 유세포분석(Flow Cytometry)에 최적화되어 있으며, 4°C 암소 보관. T세포 활성 조절 연구 및 면역학적 분석에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Flow Cytometry (Flow) | 5 µL (0.06 µg)/test |
Product Specifications
| 항목 | 내용 |
|---|---|
| Published species | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), Alexa Fluor™ 700, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3DS223H |
| Immunogen | hCD223-FC PFA 4% |
| Conjugate | Alexa Fluor™ 700 |
| Excitation/Emission Max | 696/719 nm |
| Form | Liquid |
| Concentration | 5 µL/Test |
| Storage conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping conditions | Wet ice |
| RRID | AB_2688179 |
Available Conjugate Formats
- Alexa Fluor 647
- Alexa Fluor 660
- APC
- APC-eFluor 780
- Brilliant UV 395, 563, 661, 737, 805
- Brilliant Violet 421, 480, 605, 650, 711, 786
- eFluor 450, 506
- FITC
- NovaFluor Blue 510, Blue 660-120S, Red 700, Yellow 590, 610, 700, 730
- PE, PE-Cyanine5, PE-Cyanine7, PE-eFluor 610
- PerCP-eFluor 710
- Super Bright 436, 600, 645, 702, 780
- Request custom conjugation
Product Specific Information
This 3DS223H monoclonal antibody recognizes human CD223 (LAG-3, Lymphocyte Activation Gene 3).
LAG-3 is a 70-kDa surface glycoprotein belonging to the Ig superfamily, homologous to CD4, and binds to MHC class II with higher affinity than CD4. It is involved in the negative regulation of T cell activation and homeostatic proliferation.
Surface expression of LAG-3 is reported on activated T cells (including regulatory T cells) and NK cells. CD8+ T cells usually express LAG-3 at higher levels than CD4+ T cells. Coexpression of LAG-3 and CD49b identifies human and mouse Type 1 regulatory T cells (Tr1 cells).
- Recognizes a formaldehyde-fixed epitope
- Reported for use in flow cytometric analysis
- Pre-titrated and tested for flow cytometry using stimulated normal human peripheral blood cells
- Recommended usage: 5 µL (0.06 µg) per 100 µL cell suspension (10⁵–10⁸ cells/test)
- Excitation: 633–647 nm; Emission: 723 nm; Laser: Red Laser
- Filtration: 0.2 µm post-manufacturing filtered
Target Information
LAG-3 (CD223) is a 70-kDa surface glycoprotein in the Ig superfamily with homology to CD4. It binds MHC class II with high affinity and is implicated in the negative regulation of T cell activation and proliferation. Expressed on activated T cells, regulatory T cells, and NK cells, LAG-3 is a key marker in immune regulation. Coexpression with CD49b identifies Type 1 regulatory T cells (Tr1).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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