Thermo Fisher Scientific SHP-1 Polyclonal Antibody
SHP-1(PTPN6) 단백질을 인식하는 염소 유래 폴리클로날 항체. Western blot에 적합하며, 인간 시료 반응성. 합성 펩타이드 면역원 사용, 0.5 mg/mL 농도의 액상 형태. 연구용으로만 사용 가능.
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Applications
- Western Blot (WB): 0.2–0.5 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (HTKNKREEKVKKQ) corresponding to the internal amino acids of PTPN6 (aa 568–581). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_10982197 |
Product Specific Information
This antibody is tested in Peptide ELISA: antibody detection limit dilution 128,000.
Target Information
SHP-1 (PTPN6) is a non-receptor protein tyrosine phosphatase expressed primarily in hematopoietic cells. The enzyme contains two SH2 domains, a tyrosine phosphatase catalytic domain, and a carboxy-terminal regulatory domain. SHP-1 removes phosphates from target proteins to downregulate several tyrosine kinase-regulated pathways.
In hematopoietic cells, the amino-terminal SH2 domain binds to tyrosine-phosphorylated erythropoietin receptors (EpoR) to negatively regulate hematopoietic growth. Overexpression of SHP-1 in epithelial cells leads to dephosphorylation of the Ros receptor tyrosine kinase and downregulation of Ros-dependent cell proliferation and transformation.
Following ligand binding in myeloid cells, SHP-1 associates with the IL-3R beta chain and downregulates IL-3-induced tyrosine phosphorylation and cell proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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