Thermo Fisher Scientific CD4 Monoclonal Antibody (OKT4 (OKT-4)), Biotin, eBioscience
인간 CD4 항원을 인식하는 OKT4 단클론 항체로, T 헬퍼 세포 분석에 적합. Biotin 결합형으로 유세포 분석에 최적화됨. 0.5 mg/mL 농도의 액상 제품으로 4°C 보관. 연구용으로만 사용 가능.
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Thermo Fisher Scientific CD4 Monoclonal Antibody (OKT4 (OKT-4)), Biotin, eBioscience™
Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | - | View 1 publication |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunocytochemistry (ICC/IF) | - | View 1 publication |
| Flow Cytometry (Flow) | 0.125 µg/test | View 27 publications |
| ELISA | - | View 4 publications |
| Miscellaneous PubMed | - | View 1 publication |
Product Specifications
| Item | Description |
|---|---|
| Published Species | Cynomolgus monkey, Hamster, Human, Rhesus monkey |
| Host / Isotype | Mouse / IgG2b, kappa |
| Recommended Isotype Control | Mouse IgG2b kappa Isotype Control (eBMG2b), Biotin, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OKT4 (OKT-4) |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_529524 |
Available Formats
- Unconjugated
- Alexa Fluor 488
- Alexa Fluor 700
- APC
- APC-eFluor 780
- Brilliant UV 661
- Brilliant Violet 650
- Brilliant Violet 786
- eFluor 450
- eFluor 660
- FITC
- Functional Grade
- NovaFluor Blue 610-70S
- NovaFluor Blue 660-120S
- NovaFluor Blue 690
- NovaFluor Yellow 660
- PE
- PE-Cyanine7
- PerCP-Cyanine5.5
- Super Bright 436
- Super Bright 600
- Super Bright 702
- Custom conjugation available upon request
Product Specific Information
The OKT4 monoclonal antibody reacts with human CD4, a 59 kDa cell surface glycoprotein expressed by the majority of thymocytes, a subpopulation of mature T cells (T-helper cells), and at low levels on monocytes. CD4 acts as a receptor for human immunodeficiency virus (HIV).
The OKT4 antibody recognizes a distinct epitope from the RPA-T4 monoclonal antibody; these antibodies do not cross-block each other.
Applications Reported: Flow cytometric analysis.
Applications Tested: Tested by flow cytometric analysis of normal human peripheral blood cells at ≤0.125 µg per test (100 µL final volume).
Cell number can range from 10⁵–10⁸ cells/test. Antibody should be titrated for optimal performance.
Filtration: 0.2 µm post-manufacturing filtered.
Target Information
CD4 antigen participates in MHC class II molecule recognition and serves as a co-receptor for HIV. It is primarily expressed on T helper cells but can also be found on monocytes, macrophages, and dendritic cells.
Tissue-level expression includes thymus, lymph nodes, tonsils, spleen, and certain regions of brain and gut.
CD4 contributes to early T-cell activation via interaction with T-cell receptor complex and Lck kinase, and may mediate neuronal damage in infectious or immune-mediated CNS diseases.
Multiple alternatively spliced transcripts are known (RefSeq, July 2017).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without authorization.
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