Thermo Fisher Scientific IRF8 Polyclonal Antibody
IRF8 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot과 IHC(Paraffin) 분석에 적합합니다. 다양한 종에 대해 높은 예측 반응성을 보이며, 연구용으로 면역세포 분화 및 전사 조절 연구에 활용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.2–2.5 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to a region of human IRF8 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_559720 |
Product Specific Information
- Recommended positive controls: human ovary tumor, Jurkat
- Predicted reactivity: Cow (100%), Dog (100%), Guinea Pig (100%), Horse (100%), Mouse (100%), Rabbit (100%), Rat (100%), Zebrafish (100%)
- By Western blot, PA1-24478 is specific for the ~48 kDa Interferon Regulatory Factor 8 (IRF8) protein.
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
IRF8 (Interferon Regulatory Factor 8) is a transcriptional activator or repressor that binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes. It plays a negative regulatory role in immune system cells and contributes to CD8+ dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer. This complex recognizes the AICE sequence, an immune-specific regulatory element, leading to cooperative binding and gene activation. Mutations in IRF8 can cause immunodeficiency 32A and 32B.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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