Thermo Fisher Scientific Cystatin M Monoclonal Antibody (4E7C10B7)

Applications

ELISA

• Tested Dilution: 1:1,000–1:2,000

Product Specifications

Product Specific Information

• Specificity: Human Cystatin-M / Cystatin-E / CST6

Target Information

The cystatin superfamily is a well-established family of cysteine protease inhibitors.
Cystatins A and B (type 1) are mainly intracellular; cystatins C, D, E/M, F, G, S, SN, and SA are extracellular (type 2); and the kininogens are type 3 cystatins, which are intravascular proteins.
All true cystatins inhibit cysteine peptidases of the papain family, such as cathepsins, and some also inhibit legumain family enzymes.

Cystatin SA, S, and SN are found primarily in saliva, while Cystatin S and SN can also be expressed in tears, urine, and seminal fluid.
Cystatin C is expressed in brain, thymus, ovary, epididymis, and vas deferens.
Cystatin D protects against proteinases in the oral cavity, while Cystatin E/M and F moderate the inhibition of cathepsin proteins.

The fetuins, part of the cystatin superfamily, are secretable proteins that influence osteogenesis and bone resorption, regulate insulin and hepatocyte growth factor receptors, and modulate systemic inflammation.
High and low molecular weight kininogens (HC and LC) have varied roles, both inhibiting thrombin- and plasmin-induced thrombocyte aggregation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.