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ELK Biotechnology Rpb1 CTD (phospho-Ser7) rabbit pAb
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Rpb1 CTD (phospho-Ser7)에 특이적인 rabbit polyclonal antibody로, WB 분석에 적합합니다. 인산화된 Ser7 부위를 인식하며, 핵 및 세포질 내 단백질 발현 분석에 활용 가능합니다. Human, Mouse, Rat 시료에 반응합니다.
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- pk
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ELK Biotechnology ES13339-100UL Rpb1 CTD (phospho-Ser7) rabbit pAb, 100UL pk판매 단위 pk ·
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ELK Biotechnology ES13339-50UL Rpb1 CTD (phospho-Ser7) rabbit pAb, 50UL pk판매 단위 pk ·
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301,000원VAT 포함 331,100원
ELK Biotechnology · ELK Biotechnology Rpb1 CTD (phospho-Ser7) rabbit pAb
Rpb1 CTD (phospho-Ser7) Rabbit Polyclonal Antibody
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Rpb1 CTD (phospho-Ser7) rabbit pAb |
| Alternative Names | DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6); DNA-directed RNA polymerase II subunit A; DNA-directed RNA polymerase III largest subunit; RNA-directed RNA polymerase II subunit RPB1 (EC 2.7.7.48) |
| Applications | WB |
| Recommended Dilutions | WB 1:1000–2000 |
| Immunogen | Synthesized phospho peptide around human Rpb1 CTD (Ser7) |
| Storage | -20°C, 1 year |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 250 kDa |
| Gene ID (Human) | 5430 |
| Human Swiss-Prot No. | P24928 |
| Cellular Localization | Nucleus, Cytoplasm, Chromosome. Hypophosphorylated form is mainly found in the cytoplasm, while the hyperphosphorylated and active form is nuclear (PubMed:26566685). Co-localizes with kinase SRPK2 and helicase DDX23 at chromatin loci where unscheduled R-loops form (PubMed:28076779). |
| Species Reactivity | Human, Mouse, Rat |
Background
This gene encodes the largest subunit of RNA polymerase II, the enzyme responsible for synthesizing messenger RNA in eukaryotes. The product contains a carboxy-terminal domain composed of heptapeptide repeats essential for polymerase activity. These repeats include serine and threonine residues that are phosphorylated in actively transcribing RNA polymerase. Together with other polymerase subunits, this subunit forms the DNA-binding domain of the polymerase, creating a groove in which the DNA template is transcribed into RNA.
[Provided by RefSeq, Jul 2008]
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