ELK Biotechnology Rpb1 CTD (phospho-Thr4) rabbit pAb
Rpb1 CTD (phospho-Thr4)에 특이적인 rabbit polyclonal antibody로, RNA polymerase II의 활성 형태 검출에 적합. WB에서 1:1000~2000 희석으로 사용 가능. 핵 및 세포질 내 발현 단백질 분석에 활용. -20°C에서 1년 보관 가능.
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제품명
Rpb1 CTD (phospho-Thr4) rabbit pAb
공급업체
ELK Biotechnology
제품 개요
이 항체는 인간 Rpb1 CTD의 Thr4 인산화 부위에 특이적으로 결합하는 rabbit polyclonal antibody입니다. RNA polymerase II의 활성 상태를 탐지하는 데 유용하며, 세포 내 위치 연구 및 단백질 발현 분석에 사용됩니다.
제품 스펙
| 항목 | 내용 |
|---|---|
| Alternative Names | DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48) |
| Applications | WB |
| Recommended Dilutions | WB 1:1000–2000 |
| Immunogen | Synthesized phospho peptide around human Rpb1 CTD (Thr4) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 250 kD |
| GeneID (Human) | 5430 |
| Human Swiss-Prot No | P24928 |
| Species Reactivity | Human, Mouse, Rat |
| Cellular Localization | Nucleus, Cytoplasm, Chromosome. Hypophosphorylated form mainly in cytoplasm; hyperphosphorylated and active form is nuclear (PubMed:26566685). Co-localizes with kinase SRPK2 and helicase DDX23 at chromatin loci where unscheduled R-loops form (PubMed:28076779). |
Background
This gene encodes the largest subunit of RNA polymerase II, the enzyme responsible for synthesizing messenger RNA in eukaryotes. The product contains a carboxy terminal domain composed of heptapeptide repeats essential for polymerase activity. These repeats include serine and threonine residues phosphorylated during active transcription. In combination with other polymerase subunits, this subunit forms the DNA binding domain where the DNA template is transcribed into RNA.
[provided by RefSeq, Jul 2008]
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