ELK Biotechnology Rpb1 CTD (phospho-Thr4) rabbit pAb
RNA polymerase II의 최대 소단위 Rpb1의 Thr4 인산화 형태를 인식하는 rabbit polyclonal antibody. WB에 적합하며, 핵 및 세포질에서 발현되는 단백질 검출에 유용. 고순도 IgG, 1 mg/ml 농도, -20°C에서 1년 보관 가능.
- 카탈로그번호
- ES13337-xxxxx (2개 옵션)
- 판매단위
- pk
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Rpb1 CTD (phospho-Thr4) rabbit pAb
제품 개요
Rpb1 CTD (phospho-Thr4) rabbit polyclonal antibody는 RNA polymerase II의 carboxy terminal domain(CTD) 내 Thr4 인산화 부위를 인식합니다. 이 항체는 세포 내 RNA 전사 과정 연구에 유용합니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Rpb1 CTD (phospho-Thr4) rabbit pAb |
| Alternative Names | DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6); DNA-directed RNA polymerase II subunit A; DNA-directed RNA polymerase III largest subunit; RNA-directed RNA polymerase II subunit RPB1 (EC 2.7.7.48) |
| Applications | WB |
| Recommended Dilutions | WB 1:1000–2000 |
| Immunogen | Synthesized phospho peptide around human Rpb1 CTD (Thr4) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 250 kDa |
| Gene ID (Human) | 5430 |
| Human Swiss-Prot No. | P24928 |
| Species Reactivity | Human, Mouse, Rat |
| Cellular Localization | Nucleus, Cytoplasm, Chromosome. Hypophosphorylated form is mainly found in the cytoplasm, while the hyperphosphorylated and active form is nuclear (PubMed:26566685). Co-localizes with kinase SRPK2 and helicase DDX23 at chromatin loci where unscheduled R-loops form (PubMed:28076779). |
Background
This gene encodes the largest subunit of RNA polymerase II, the enzyme responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a carboxy terminal domain composed of heptapeptide repeats essential for polymerase activity. These repeats contain serine and threonine residues that are phosphorylated in actively transcribing RNA polymerase. In combination with other polymerase subunits, this subunit forms the DNA binding domain of the polymerase, creating a groove in which the DNA template is transcribed into RNA.
[Provided by RefSeq, Jul 2008]
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