Thermo Fisher Scientific ASGR1 Polyclonal Antibody
Thermo Fisher Scientific의 ASGR1 Polyclonal Antibody는 인간 ASGR1 단백질을 인식하는 토끼 유래 다클론 항체입니다. Western blot에 적합하며, 고순도의 affinity chromatography 정제 제품입니다. PBS buffer에 보관되며, 연구용으로만 사용 가능합니다.
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Applications
- Western Blot (WB): 0.2–1.0 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the middle region of human ASGR1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2688993 |
Product Specific Information
This target displays homology in the following species:
Cow: 85%; Guinea Pig: 92%; Horse: 86%; Human: 100%; Mouse: 91%; Pig: 93%; Rat: 92%; Yeast: 75%
Target Information
The asialoglycoprotein receptor (ASGPR) is a 42 kDa transmembrane glycoprotein that mediates binding, internalization, and degradation of extracellular glycoproteins with exposed terminal galactose residues.
It is expressed on the surface of hepatocytes in a polar manner—present on sinusoidal and lateral plasma membranes but not on the bile canalicular membrane.
Mammalian hepatic ASGPR mediates endocytosis and degradation of serum proteins lacking terminal sialic residues.
The rat ASGPR consists of three polypeptide subunits: RHL-1, RHL-2, and RHL-3. The monoclonal antibody 8D7 recognizes a subunit-specific epitope of RHL-1 and is cross-reactive with human ASGPR.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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