Thermo Fisher Scientific C16orf62 Polyclonal Antibody
인간 C16orf62 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체입니다. IHC(P)에서 1:200~1:500 희석으로 사용 가능하며, 항원 친화 크로마토그래피로 정제되었습니다. PBS 기반 용액으로 4°C 단기, -20°C 장기 보관이 가능합니다.
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Thermo Fisher Scientific C16orf62 Polyclonal Antibody
Applications
- Immunohistochemistry (Paraffin) (IHC (P)): Tested dilution 1:200–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human C16orf62. Recombinant protein control fragment (Product # RP-98634) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2638797 |
Product Specific Information
Immunogen sequence:
ENNKLCETVM AQILEHLKTL AKDEALKRQS SLGLSFFNSI LAHGDLRNNK LNQLSVNLWH LAQRHGCADT RTMVKTLEYI KKQSKQPDMT HLTELA
Highest antigen sequence identity to orthologs:
- Mouse: 93%
- Rat: 91%
Target Information
Acts as a component of the retriever complex, a heterotrimeric complex related to the retromer cargo-selective complex (CSC). It is essential for retromer-independent retrieval and recycling of numerous cargos such as integrin alpha-5/beta-1 (ITGA5:ITGB1).
The retriever complex recruitment to endosomal membranes involves CCC and WASH complexes. In endosomes, it drives retrieval and recycling of NxxY-motif-containing cargo proteins by coupling to SNX17, maintaining numerous cell surface proteins involved in cell migration, adhesion, nutrient supply, and signaling.
Also involved in copper-dependent ATP7A trafficking between the trans-Golgi network and peripheral vesicles, likely depending on association with CCC and WASH complexes. Not required for CCC complex stability.
[UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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