Thermo Fisher Scientific SMAD4 Recombinant Rabbit Monoclonal Antibody (SP05-05)
SMAD4 단백질을 인식하는 Thermo Fisher Scientific의 재조합 토끼 단클론 항체. Western blot, IHC, ICC/IF, Flow cytometry 등 다양한 응용 가능. 높은 특이성과 재현성을 제공하며, HEK293 시스템에서 발현된 IgG 형 항체로 연구용에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| Flow Cytometry (Flow) | 1:50–1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | SP05-05 |
| Immunogen | Synthetic peptide within C-terminal human Smad4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 0.05% BSA, 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2898855 |
Target Information
Smad4 is encoded by the Smad4 gene located on chromosome 18 in humans. It is also known as Smad family member 4, Sma- and Mad-related protein 4, or Mothers against decapentaplegic (MAD) homolog 4.
Smad4 contains N-terminal MH1 (MAD homology 1) and C-terminal MH2 (MAD homology 2) domains that mediate DNA binding and protein interactions.
Upon binding of TGF-beta superfamily ligands (including TGF-beta and BMP) to their receptors, Smad 1, 2, 3, 5, and 8 are phosphorylated, forming heterotrimers with Smad4 and translocating to the nucleus.
Smad4 functions as a tumor suppressor by regulating genes such as Cyclin D1 (downregulation) and collagen (upregulation), thereby controlling cell proliferation.
Dephosphorylation regulates nuclear export and nucleocytoplasmic dynamics of Smads.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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