Thermo Fisher Scientific FANCD2 Polyclonal Antibody
FANCD2 단백질을 표적하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western Blot, ICC/IF, ELISA, IP에 적합. 인간 및 랫트 반응성. 액상 형태, 1.1 mg/mL 농도, -20°C 보관. DNA 손상 복구 연구에 활용.
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- PA5120776
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- pk
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Thermo Fisher Scientific FANCD2 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
| Immunoprecipitation (IP) | 0.5–4 µg antibody for 200–400 µg extracts |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 540–720 of FANCD2 (NP_001018125.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.1 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | –20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2914348 |
Product Specific Information
- Positive test controls: MCF7, HeLa, K-562, Jurkat, A-549
- Localization: Nucleus
Immunogen sequence:
AFSKQNEASS HIQDDMHLVI RKQLSSTVFK YKLIGIIGAV TMAGIMAADR SESPSLTQER ANLSDEQCTQ VTSLLQLVHS CSEQSPQASA LYYDEFANLI QHEKLDPKAL EWVGHTICND FQDAFVVDSC VVPEGDFPFP VKALYGLEEY DTQDGIAINL LPLLFSQDFA KDGGPVTSQE S
Target Information
FANCD2 (Fanconi anemia group D2 protein) is required for maintenance of chromosomal stability. It promotes accurate and efficient pairing of homologs during meiosis and is involved in the repair of DNA double-stranded breaks via homologous recombination and single-stranded annealing. FANCD2 stabilizes BLM at abnormal replication structures and promotes BRCA2/FANCD1 loading onto damaged chromatin. Mutations in FANCD2 cause Fanconi anemia complementation group D2, affecting bone marrow and leading to anemia, leukopenia, and thrombopenia.
⚠ WARNING: This product contains mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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