Thermo Fisher Scientific BK channel Polyclonal Antibody
BK 채널을 인식하는 Rabbit Polyclonal 항체로, Human, Mouse, Rat 시료에 반응합니다. IHC(P) 및 IHC(F) 실험에 적합하며, Protein A로 정제된 액상 형태입니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
Immunohistochemistry (Paraffin) (IHC (P))
- Dilution: 1:200–1:400
Immunohistochemistry (Frozen) (IHC (F))
- Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from human BK channel (amino acids 1151–1236) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Potassium channels are ubiquitously expressed proteins that perform various functions in excitable and non-excitable cells.
The large conductance, calcium-activated potassium channel (Maxi K⁺) differs from other potassium channels as it is activated by both intracellular calcium increase and membrane depolarization.
This dual activation is due to its structure — a Maxi K⁺ alpha homotetramer containing a voltage sensor and an intracellular calcium-binding domain.
In vascular smooth muscle, an auxiliary beta-subunit (1:1 stoichiometry) modulates the channel by reducing the calcium concentration required to keep the pore open by approximately 5–10 fold.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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