Thermo Fisher Scientific PSMB6 Polyclonal Antibody

Applications

Product Specifications

Target Information

Proteolytic degradation is critical to maintaining appropriate levels of short-lived and regulatory proteins involved in cellular metabolism, stress response, antigen presentation, modulation of cell surface receptors and ion channels, cell cycle regulation, transcription, and signaling.
The ubiquitin-proteasome pathway deconstructs most proteins in the eukaryotic cell cytosol and nucleus, while others are degraded via the vacuolar pathway including endosomes, lysosomes, and the endoplasmic reticulum.

The 26S proteasome is an ATP-dependent, multisubunit (~31), barrel-shaped molecular complex (~2.5 MDa) consisting of a 20S proteolytic core and one or two 19S regulatory subunits. The 19S subunits recognize ubiquitinated proteins and facilitate their unfolding and translocation into the 20S core.

The PA28/11S REG Activator complex, composed of alpha, beta, and gamma subunits, enhances the activity of the 20S proteolytic core. An enzymatic cascade attaches multiple ubiquitin molecules to lysine residues of target proteins.

Defects in the ubiquitin-proteasome pathway are associated with genetic diseases such as cystic fibrosis (CF transmembrane regulator), Angelman’s syndrome (E6-AP), and Liddle syndrome (endothelial sodium channels).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.