Thermo Fisher Scientific Human FGFR3 Synthetic Peptide
FGFR3 단백질의 C-말단 19개 아미노산 서열을 기반으로 한 합성 펩타이드입니다. Western blot 차단 실험에 사용 가능하며, 인간 FGFR3 특이적입니다. PBS 기반의 액상 형태로 제공되며 -20°C에서 보관합니다. 연구용으로만 사용됩니다.
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Thermo Fisher Scientific Human FGFR3 Synthetic Peptide
Applications
- Control (Ctrl): Assay-dependent
- Blocking Assay (BLOCK): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 19 amino acids near the carboxy terminus of FGFR3.
PEP-1617 can be used as a blocking peptide with polyclonal antibody PA5-34574.
For use as a blocking peptide in Western blot, incubate the peptide with equal volume of antibody for 30 min at 37ºC.
Target Information
FGFR3 is a member of the FGFR family of receptor tyrosine kinases. This family regulates cellular functions such as angiogenesis, mitogenesis, osteogenesis, myogenesis, carcinogenesis, cellular differentiation, and tissue repair after injury.
FGFR family members differ in ligand affinities and tissue distribution. The full-length protein includes:
- Extracellular region with three immunoglobulin-like domains
- Single hydrophobic membrane-spanning segment
- Cytoplasmic tyrosine kinase domain
The extracellular portion interacts with fibroblast growth factors, triggering downstream signals that influence mitogenesis and differentiation. FGFR3 plays a role in bone development and maintenance. Mutations in this gene are associated with craniosynostosis and various skeletal dysplasias. Three alternatively spliced transcript variants encoding different isoforms have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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