Thermo Fisher Scientific TNFRSF18 Monoclonal Antibody (OTI4A9), TrueMAB
TNFRSF18 단백질을 인식하는 Mouse IgG1 단클론 항체로, Western blot 및 유세포분석에 사용 가능. 인간 TNFRSF18(AA 26-162) 재조합 단백질을 면역원으로 제작. 동결건조 형태, 1 mg/mL 농도, 보존제 무첨가. 연구용으로만 사용.
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Thermo Fisher Scientific TNFRSF18 Monoclonal Antibody (OTI4A9), TrueMAB
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Flow Cytometry (Flow) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4A9 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 26–162 of human TNFRSF18 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | −20 °C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
Tumor necrosis factor receptor superfamily member 18 (TNFRSF18), also known as GITR or AITR, is encoded by the TNFRSF18 gene located at 1p36.33.
This receptor is a member of the TNF-receptor superfamily and is upregulated upon T-cell activation. It plays a key role in immunological self-tolerance maintained by CD25⁺CD4⁺ regulatory T cells.
Knockout studies in mice indicate its involvement in CD3-driven T-cell activation and programmed cell death.
Three alternatively spliced transcript variants encoding distinct isoforms have been reported.
Usage Note
For Research Use Only. Not for use in diagnostic procedures.
Not for resale without express authorization.
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