Thermo Fisher Scientific SRC2 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:3,000

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:100–1:1,000

Product Specifications

Product Specific Information

• Recommended positive controls: HeLa Nucleus
• Predicted reactivity: Mouse (89%), Rat (93%), Pig (95%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

SRC2 (steroid receptor coactivator 2), also known as nuclear receptor coactivator 2 (NCOA2, TIF2), aids in the function of nuclear hormone receptors.
Nuclear hormone receptors are conditional transcription factors that regulate cell growth, development, and homeostasis by controlling gene expression.
These receptors contain three structural domains:

1. N-terminal transcriptional activation domain
2. Central DNA-binding domain
3. C-terminal hormone-binding domain

Before hormone binding, steroid receptors remain inactive in a complex with heat-shock protein-90 and other stress family proteins.
Hormone binding induces conformational changes, enabling receptors to dissociate from inhibitory complexes, bind DNA enhancer elements as homodimers, and modulate transcription.
Transcriptional coactivator proteins such as SRC2 mediate transcription initiation after receptor binding.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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