Thermo Fisher Scientific CD171/NCAM-L1 (L1 Cell Adhesion Molecule) Monoclonal Antibody (SPM275)
인간 CD171/L1CAM을 인식하는 Mouse monoclonal antibody (Clone SPM275). IHC(F), ICC/IF, Flow Cytometry에 적합. Protein A/G 정제, PBS buffer 내 200 µg/mL 농도. 신경세포 부착 및 발달 연구용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Frozen) (IHC (F)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10⁶ cells |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | SPM275 |
| Immunogen | Homogenous suspension of 16-week human fetal brain |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
L1CAM (CD171) is an axonal glycoprotein belonging to the immunoglobulin supergene family. Its ectodomain, consisting of immunoglobulin-like and fibronectin type III repeats, is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This molecule plays a critical role in nervous system development, including neuronal migration and differentiation.
Mutations in the L1CAM gene are associated with X-linked neurological syndromes collectively known as CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia, and hydrocephalus).
Alternative splicing of a neuron-specific exon may have functional significance.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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