Thermo Fisher Scientific SGOL2 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human SGO2. Recombinant protein control fragment (Product #RP-105993). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:SGOL2,uniProtId:Q562F6-1,ncbiNodeId:9606,antigenRange:1160-1250,antigenLength:1265,antigenImageFileName:PA5-83519_SGOL2_Q562F6-1_Rabbit.svg,antigenImageFileNamePDP:PA5-83519_SGOL2_Q562F6-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2790672

Product Specific Information

Immunogen sequence: VPLSVSSGKN VIIKENFALE CSPAFQVSDD EHEKMNKMKF KVNRRTQKSG IGDRPLQDLS NTSFVSNNTA ESENKSEDLS SERTSRRRRC T

Target Information

Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Has a crucial role in protecting REC8 at centromeres from cleavage by separase. During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis. May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation. Essential for recruiting KIF2C to the inner centromere and for correcting defective kinetochore attachments. Involved in centromeric enrichment of AUKRB in prometaphase. [UniProt]

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.