Thermo Fisher Scientific SGOL2 Polyclonal Antibody
인간 SGOL2 단백질을 인식하는 토끼 폴리클로날 항체로, 면역세포화학(ICC/IF)에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, PBS와 글리세롤 버퍼에 보관됩니다. 단기 4°C, 장기 -20°C 보관 권장.
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human SGO2. Recombinant protein control fragment (Product #RP-105993) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2790672 |
Product Specific Information
Immunogen sequence:
VPLSVSSGKN VIIKENFALE CSPAFQVSDD EHEKMNKMKF KVNRRTQKSG IGDRPLQDLS NTSFVSNNTA ESENKSEDLS SERTSRRRRC T
Target Information
Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I.
Has a crucial role in protecting REC8 at centromeres from cleavage by separase.
During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres.
Is thus essential for accurate gametogenesis.
May act by targeting PPP2CA to centromeres, leading to cohesin dephosphorylation.
Essential for recruiting KIF2C to the inner centromere and for correcting defective kinetochore attachments.
Involved in centromeric enrichment of AUKRB in prometaphase.
[UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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