Thermo Fisher Scientific TNNI2 Monoclonal Antibody (2F12A8)
TNNI2 단백질을 타겟으로 하는 Mouse IgG1 단클론 항체. Western blot, IHC, Flow cytometry, ELISA 등 다양한 응용에 적합. 인간 및 마우스 시료 반응성. 비결합형 액상 형태로 제공되며 4°C 단기, -20°C 장기 보관 가능.
- 카탈로그번호
- MA515913
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:1,000 |
| Flow Cytometry (Flow) | 1:200–1:400 |
| ELISA | 1:10,000 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2F12A8 |
| Immunogen | Purified recombinant fragment of human TNNI2 expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not determined |
| Storage Buffer | Ascites |
| Contains | 0.03% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C avoiding freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_11156210 |
Product Specific Information
MA5-15913 targets TNNI2 in indirect ELISA, FACS, IHC, and WB applications and shows reactivity with human samples.
The immunogen is a purified recombinant fragment of human TNNI2 expressed in E. coli.
MA5-15913 detects TNNI2, which has a predicted molecular weight of approximately 21 kDa.
Target Information
The TNNI2 gene encodes a fast-twitch skeletal muscle protein, part of the troponin I family and a component of the troponin complex (troponin T, C, and I subunits). This complex, together with tropomyosin, regulates calcium-dependent striated muscle contraction.
Mouse studies indicate expression in vascular smooth muscle, suggesting a role in smooth muscle regulation.
Beyond muscle tissues, TNNI2 is found in corneal epithelium and cartilage, acting as an angiogenesis inhibitor to suppress tumor growth and metastasis. In mammary glands, it functions as a co-activator of estrogen receptor-related receptor alpha.
This protein suppresses tumor growth in human ovarian carcinoma. Mutations in this gene are associated with myopathy and distal arthrogryposis type 2B.
Alternatively spliced transcript variants have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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