Thermo Fisher Scientific DFF45/DFFA Polyclonal Antibody
Rabbit polyclonal antibody recognizing human DFF45/DFFA (ICAD), suitable for IHC and IHC-P applications. Affinity purified, unconjugated, supplied in TBS buffer with BSA and sodium azide. Recommended storage at 4°C. For research use only.
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Applications
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (IHC) | 1:50–1:500 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:100–1:500 |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 271 and 331 of human DNA fragmentation factor, 45 kDa, alpha polypeptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.10 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4 °C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Orangutan, Chimpanzee, and Northern white-cheeked gibbon.
Target Information
ICAD (Inhibitor of Caspase-activated DNase) regulates nuclear apoptosis by controlling CAD (Caspase-activated DNase). It exists as two isoforms:
- ICAD-L/DFF45 (45 kDa): functional isoform
- ICAD-S/DFF35 (35 kDa): non-functional isoform
ICAD binds and inhibits CAD under non-apoptotic conditions. Upon apoptotic signaling, caspase 3 cleaves ICAD at residues 117 and 224, releasing CAD to fragment nuclear DNA. ICAD also acts as a folding chaperone for CAD. It has been studied as a potential therapeutic target for restoring apoptotic signaling in colon and brain cancers. Two alternatively spliced transcript variants encode distinct isoforms of ICAD.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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