Thermo Fisher Scientific HMGB1 Monoclonal Antibody (GT348)
HMGB1 단백질을 표적하는 Thermo Fisher Scientific의 단클론 항체로, Western blot, IHC, ICC 등 다양한 응용에 적합합니다. Human, Mouse, Rat 반응성을 가지며, Protein G로 정제된 액상 형태 제품입니다. 염증 및 세포 신호 연구에 유용합니다.
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Thermo Fisher Scientific HMGB1 Monoclonal Antibody (GT348)
Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:3,000 | View 3 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 | - |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:1,000 | - |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 | View 1 publication |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human, Mouse |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | GT348 |
| Immunogen | Recombinant fragment corresponding to amino acids 2–159 of HMGB1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.88 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C (avoid freeze/thaw cycles) |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2538744 |
Product Specific Information
- Recommended positive controls: 293T, A431, HepG2, Neuro2A, C8D30, NIH-3T3, BCL-1, Raw264.7, C2C12, PC-12, Rat2, mouse brain, rat brain
- Predicted reactivity: Mouse (100%), Rat (100%), Xenopus laevis (93%), Dog (100%), Pig (100%), Rabbit (100%), Chicken (94%), Rhesus Monkey (100%), Bovine (100%)
- Store product as a concentrated solution. Centrifuge briefly before opening the vial.
Target Information
HMGB1 (High-mobility group box-1) protein is a nuclear non-histone DNA-binding chromosomal protein. Damaged or necrotic cells release HMGB1 extracellularly, where it acts as a proinflammatory cytokine. Mouse HMGB1 is a 215 amino acid polypeptide with three domains: two positively charged DNA-binding domains (HMG box A: aa 9–79, box B: aa 89–162) and a negatively charged 30 aa C-terminal acidic tail. Nuclear localization signals are found at residues 28–44 and 180–185.
HMGB1 mediates inflammation, monocyte migration, cytokine secretion, and T cell–dendritic cell interactions. It signals through receptors such as RAGE, TLR2, and TLR4. HMGB1 is highly conserved and expressed in nearly all cell types, acting as a key mediator of sterile and infection-associated inflammation. Elevated HMGB1 levels are linked to tissue injury, sepsis, arthritis, and ischemia-reperfusion injury.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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