Thermo Fisher Scientific Phospho-EphB1 (Tyr928) Polyclonal Antibody

Thermo Fisher Scientific Phospho-EphB1 (Tyr928) Polyclonal Antibody

Applications

• Western Blot (WB): 1:1,000–1:3,000

Product Specifications

Product Specific Information

This antibody detects endogenous levels of EPHB1 only when phosphorylated at Tyr928.

Target Information

EPHB1 is a receptor tyrosine kinase belonging to the ephrin receptor family. Members of the Eph family play key roles in biological processes such as nervous system development, angiogenesis, and neural synapse formation and maturation.
EphB1 and other EphB family proteins are type I membrane-spanning proteins composed of immunoglobulin, fibronectin type III, and cysteine-rich subdomains in the ectodomain, with a single uninterrupted cytoplasmic tyrosine kinase domain upstream of a carboxyterminal sterile alpha motif (SAM) domain.
EphB family proteins bind ephrin-B class ligands, which are transmembrane proteins capable of bidirectional signaling. EphB1 is predominantly expressed in developing neural structures and vascular epithelium of kidney and other tissues. Upon binding to ephrin B1, EphB1 mediates regulation of cell attachment and assembly. Members of this family are implicated in neuronal and vascular cell targeting.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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