Thermo Fisher Scientific SATB2 Polyclonal Antibody
Human SATB2 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB 및 IHC(P) 실험에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, PBS(40% glycerol) 용액 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,000–1:2,500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human SATB2. Recombinant protein control fragment (Product # RP-93680) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.3 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2789075 |
Product Specific Information
Immunogen sequence:
VSQAVFARVA FNRTQGLLSE ILRKEEDPRT ASQSLLVNLR AMQNFLNLPE VERDRIYQDE RERSMNPNVS MVSSASSSPS SSRTPQAKTS TPTTDLPIKV DGANINITAA IYDEIQQEMK RAK
Target Information
DNA-binding protein SATB2 binds to DNA at the nuclear matrix- or scaffold-associated regions and recognizes the sugar-phosphate structure of double-stranded DNA.
SATB2 functions as a transcription factor controlling nuclear gene expression by binding to matrix attachment regions (MARs) of DNA and inducing local chromatin-loop remodeling.
It acts as a docking site for chromatin remodeling enzymes, recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers.
SATB2 is required for the initiation of upper-layer neuron (UL1) genetic programs and repression of deep-layer neuron (DL) and UL2 genes, likely through modulation of BCL11B expression.
It serves as a repressor of Ctip2 and a regulatory determinant of corticocortical connections in the developing cerebral cortex.
Mutations in SATB2 are associated with cleft palate isolated (CPI).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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