
ELK Biotechnology PDE3A rabbit pAb
PDE3A 단백질을 인식하는 토끼 폴리클로날 항체로, WB 및 ELISA에 사용 가능. 세포 내 cAMP와 cGMP 신호 조절 연구에 적합하며, 심혈관 기능 및 혈소판 응집 관련 연구에 활용 가능. -20°C에서 1년 보관.
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PDE3A rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | PDE3A rabbit pAb |
| Applications | WB; ELISA |
| Recommended Dilutions | WB 1:500–2000, ELISA 1:5000–20000 |
| Immunogen | Synthesized peptide derived from human protein (AA range: 250–330) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 125 kD |
| Gene ID (Human) | 5139 |
| Human Swiss-Prot No. | Q14432 |
| Cellular Localization | Membrane; Multi-pass membrane protein; Cytoplasm, cytosol |
| Species Reactivity | Human; Mouse; Rat |
Background
This gene encodes a member of the cGMP-inhibited cyclic nucleotide phosphodiesterase (cGI-PDE) family. cGI-PDE enzymes hydrolyze both cAMP and cGMP, and play critical roles in many cellular processes by regulating the amplitude and duration of intracellular cyclic nucleotide signals. The encoded protein mediates platelet aggregation and also plays important roles in cardiovascular function by regulating vascular smooth muscle contraction and relaxation. Inhibitors of the encoded protein may be effective in treating congestive heart failure. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
[provided by RefSeq, Sep 2011]
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