ELK Biotechnology ASAP2 rabbit pAb

제품명

ASAP2 rabbit pAb

제품 개요

ASAP2 단백질을 인식하는 토끼 폴리클로날 항체로, WB 및 ELISA 분석에 적합합니다. 세포 내 골지체 및 세포막에 위치한 단백질의 검출에 활용됩니다.

제품 정보

Background

This gene encodes a multidomain protein containing an N-terminal alpha-helical region with a coiled-coil motif, followed by a pleckstrin homology (PH) domain, an Arf-GAP domain, an ankyrin homology region, a proline-rich region, and a C-terminal Src homology 3 (SH3) domain.
The protein localizes in the Golgi apparatus and at the plasma membrane, where it colocalizes with protein tyrosine kinase 2-beta (PYK2). The encoded protein forms a stable complex with PYK2 in vivo, mediated by binding of its SH3 domain to the C-terminal proline-rich domain of PYK2.
It is tyrosine phosphorylated by activated PYK2 and has catalytic activity for class I and II ArfGAPs in vitro, while binding the class III Arf ARF6 without immediate GAP activity. The encoded protein is believed to function as an ARF GAP that controls ARF-mediated vesicle trafficking.