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ELK Biotechnology SRBP2 rabbit pAb
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ELK Biotechnology SRBP2 rabbit pAb

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SRBP2 단백질을 인식하는 토끼 폴리클로날 항체로, WB 및 ELISA에 적합합니다. 인간, 마우스, 랫트 시료에 반응하며, 콜레스테롤 항상성 관련 전사 인자 연구에 유용합니다. -20°C에서 1년 보관 가능합니다.

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pk
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ELK Biotechnology ES8983-100UL SRBP2 rabbit pAb, 100UL pk판매 단위 pk ·
재고 확인 필요
402,000원VAT 포함 442,200원
ELK Biotechnology ES8983-50UL SRBP2 rabbit pAb, 50UL pk판매 단위 pk ·
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301,000원VAT 포함 331,100원

ELK Biotechnology · ELK Biotechnology SRBP2 rabbit pAb

SRBP2 rabbit pAb

제품 정보

항목 내용
Product name SRBP2 rabbit pAb
Applications WB, ELISA
Recommended Dilutions WB: 1:500–1:2000, ELISA: 1:5000–1:20000
Immunogen Synthesized peptide derived from human protein (AA range: 390–470)
Host Rabbit
Storage -20°C, 1 year
Clonality Polyclonal
Isotype IgG
Concentration 1 mg/ml
Observed Band 125 kDa
Gene ID (Human) 6721
Human Swiss-Prot No. Q12772
Species Reactivity Human, Mouse, Rat

Cellular Localization

  • Sterol regulatory element-binding protein 2 (SREBP2):
    Endoplasmic reticulum membrane, multi-pass membrane protein; Golgi apparatus membrane, multi-pass membrane protein; cytoplasmic vesicle (COPII-coated vesicle membrane).
    At high sterol concentrations, the SCAP-SREBP complex is retained in the endoplasmic reticulum (PubMed:32322062).
    Low sterol concentrations promote recruitment into COPII-coated vesicles and transport of the SCAP-SREBP to the Golgi, where it is processed (PubMed:32322062).
  • Processed SREBP2:
    Localized in the nucleus; transported into the nucleus via importin-β. Dimerization of the bHLH domain is required for importin-β-dependent nuclear import.

Background

This gene encodes a ubiquitously expressed transcription factor that controls cholesterol homeostasis by regulating transcription of sterol-regulated genes.
The encoded protein contains a basic helix-loop-helix-leucine zipper (bHLH-Zip) domain and binds the sterol regulatory element 1 motif.
Alternative splicing results in multiple transcript variants.
[Provided by RefSeq, Jul 2013]

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