ELK Biotechnology NUAK1 rabbit pAb

제품명

NUAK1 rabbit pAb

제품 설명

NUAK1 단백질을 인식하는 토끼 폴리클로날 항체입니다. Western blot(WB) 및 ELISA 분석에 사용되며, 인간 단백질에서 유래한 합성 펩타이드를 면역원으로 제작되었습니다. NUAK1은 세포 내 에너지 대사 및 세포사멸 조절에 관여하는 단백질로, 본 항체는 해당 단백질의 연구에 유용합니다.

제품 스펙

Background

• Catalytic activity: ATP + a protein = ADP + a phosphoprotein
• Cofactor: Magnesium
• Enzyme regulation: Activated by PKB/AKT1 during glucose starvation. Activated by phosphorylation on Thr-211 by STK11 in complex with STE20-related adapter-alpha (STRADα) pseudo kinase and CAB39.
• Function: Involved in tolerance to glucose starvation. Phosphorylates ATM. Suppresses Fas-induced apoptosis by phosphorylation of CASP6, thus suppressing activation of caspase and cleavage of CFLAR.
• Similarity: Belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family, SNF1 subfamily. Contains one protein kinase domain.
• Tissue specificity: Expressed at high levels in heart and brain, and at lower levels in skeletal muscle, kidney, ovary, placenta, lung, and liver.