ELK Biotechnology Collagen I rabbit pAb
Type I Collagen에 대한 rabbit polyclonal antibody로, WB 및 ELISA에 사용 가능. 인간, 마우스, 랫트 시료에 반응. 세포외 기질 단백질 검출에 적합하며, -20°C에서 1년 보관 가능.
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제품명
Collagen I rabbit pAb
제품 개요
Type I Collagen의 pro-alpha2 chain을 인식하는 rabbit polyclonal antibody입니다. 인체, 마우스, 랫트 시료에서 사용 가능하며, 주로 세포외 기질 단백질 연구에 활용됩니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Collagen I rabbit pAb |
| Alternative Names | Collagen alpha-2(I) chain (Alpha-2 type I collagen) |
| Applications | WB; ELISA |
| Recommended Dilutions | WB 1:500–2000, ELISA 1:10000–20000 |
| Immunogen | Synthesized peptide derived from human Collagen I Polyclonal |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 115 kD |
| Gene ID (Human) | 1278 |
| Human Swiss-Prot No. | P08123 |
| Cellular Localization | Secreted, extracellular space, extracellular matrix |
| Species Reactivity | Human; Mouse; Rat |
Background
This gene encodes the pro-alpha2 chain of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis, and tendon.
Mutations in this gene are associated with osteogenesis imperfecta types I–IV, Ehlers-Danlos syndrome type VIIB, recessive Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and atypical Marfan syndrome.
Symptoms associated with mutations in this gene tend to be less severe than those in the alpha1 chain (COL1A1), reflecting the different role of alpha2 chains in matrix integrity. Three transcripts resulting from alternate polyadenylation signals have been identified for this gene.
[provided by R. Dalgleish, Feb 2008]
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