ELK Biotechnology Tip60 rabbit pAb
Histone acetyltransferase Tip60 단백질을 인식하는 rabbit polyclonal antibody. WB 및 IHC에 적합하며, 핵 및 세포질 내 Tip60 검출에 사용. 인간, 마우스, 랫트 반응성. 고순도 IgG, 1 mg/ml 농도, -20°C에서 1년 보관.
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제품명
Tip60 rabbit pAb
기본 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | Histone acetyltransferase KAT5 (EC 2.3.1.48), 60 kDa Tat-interactive protein (Tip60), Histone acetyltransferase HTATIP, HIV-1 Tat interactive protein, Lysine acetyltransferase 5, cPLA(2)-interacting protein |
| Applications | WB; IHC |
| Recommended Dilutions | WB 1:500–2000; IHC-p 1:50–300 |
| Immunogen | Synthesized peptide derived from human Tip60 |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 60 kD |
| GeneID (Human) | 10524 |
| Human Swiss-Prot No | Q92993 |
| Species Reactivity | Human; Mouse; Rat |
세포 내 위치 (Cellular Localization)
Nucleus, Chromosome, Cytoplasm, Chromosome (centromere, kinetochore), Cytoplasm (cytoskeleton, spindle pole), Nucleus (nucleolus), Cytoplasm (perinuclear region).
Upon stimulation with EDN1, Tip60 is exported from the nucleus to the perinuclear region. UV irradiation induces translocation into punctuate subnuclear structures named nuclear bodies (PubMed:11262386).
Transiently localizes to kinetochores in early mitosis (PubMed:26829474). Localizes to spindle poles during metaphase (PubMed:34608293).
Also found in the cytoplasm and nucleus of round spermatids (By similarity).
Background
The protein encoded by this gene belongs to the MYST family of histone acetyltransferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein.
HATs play important roles in chromatin remodeling, transcription, and other nuclear processes by acetylating histone and non-histone proteins.
Tip60 functions as a histone acetylase involved in DNA repair and apoptosis and is thought to play an important role in signal transduction.
Alternative splicing results in multiple transcript variants. (Provided by RefSeq, Jul 2008)
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