ELK Biotechnology TIE2 rabbit pAb
TIE2 rabbit pAb는 인간, 마우스, 랫트에 반응하는 다클론 항체로 WB, IHC, IF, ELISA에 적합합니다. 인간 TIE2 단백질 유래 펩타이드로 면역화되었으며, 세포막 및 세포골격에 위치한 TIE2 단백질 검출에 사용됩니다. -20°C에서 1년 보관 가능합니다.
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제품명
TIE2 rabbit pAb
공급업체
ELK Biotechnology
제품 설명
TIE2 rabbit pAb는 인간 TIE2 단백질에서 유래한 합성 펩타이드를 면역원으로 제작된 다클론 항체입니다. 혈관 내피세포에서 발현되는 TIE2 수용체를 검출할 수 있으며, 다양한 응용 분야(WB, IHC, IF, ELISA)에 적합합니다.
제품 스펙
| 항목 | 내용 |
|---|---|
| Product name | TIE2 rabbit pAb |
| Alternative Names | Angiopoietin-1 receptor (EC 2.7.10.1; Endothelial tyrosine kinase; Tunica interna endothelial cell kinase; Tyrosine kinase with Ig and EGF homology domains-2; Tyrosine-protein kinase receptor TEK; Tyrosine-protein kinase receptor TIE-2; hTIE2; p140 TEK; CD antigen CD202b) |
| Applications | WB, IHC, IF, ELISA |
| Recommended Dilutions | IHC-p: 100–300; WB: 1:500–2000; ELISA: 1:10000–20000 |
| Immunogen | Synthesized peptide derived from human TIE2 Polyclonal |
| Species Reactivity | Human, Mouse, Rat |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 120 kDa |
| GeneID (Human) | 7010 |
| Human Swiss-Prot No | Q02763 |
| Storage | -20°C / 1 year |
| Host | Rabbit |
세포 내 위치
Cell membrane; Single-pass type I membrane protein.
Cell junction; focal adhesion; cytoplasm, cytoskeleton; secreted.
Recruited to cell-cell contacts in quiescent endothelial cells (PubMed:18425120, PubMed:18425119).
Colocalizes with actin cytoskeleton and actin stress fibers during cell spreading.
Recruited to the lower surface of migrating cells, especially the rear end of the cell.
Proteolytic processing gives rise to a soluble extracellular domain that is secreted (PubMed:11806244).
Background
This gene encodes a receptor belonging to the protein tyrosine kinase Tie2 family.
The encoded protein contains two immunoglobulin-like domains, three EGF-like domains, and three fibronectin type III repeats.
Angiopoietin-1 binds to this receptor to mediate signaling in embryonic vascular development.
Mutations are associated with inherited venous malformations of the skin and mucous membranes.
Alternative splicing results in multiple transcript variants, some of which have uncharacterized full-length forms.
[provided by RefSeq, Feb 2014]
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