ELK Biotechnology Na+/K+-ATPase α1 (Phospho-Tyr260) rabbit pAb
Na+/K+-ATPase α1 (Phospho-Tyr260) 인산화 특이 항체로, WB 및 IHC에 적합합니다. 사람, 마우스, 랫트 시료에서 반응하며, 세포막 단백질의 인산화 연구에 유용합니다. -20°C에서 1년 보관 가능합니다.
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제품명
Na+/K+-ATPase α1 (Phospho-Tyr260) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | Sodium/potassium-transporting ATPase subunit alpha-1 (Na(+)/K(+) ATPase alpha-1 subunit), Sodium pump subunit alpha-1 |
| Applications | WB, IHC |
| Recommended Dilutions | WB 1:500–2000; IHC-p 1:50–300 |
| Immunogen | Synthesized phospho peptide derived from human Na+/K+-ATPase α1 (Phospho-Tyr260) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 115 kD |
| Gene ID (Human) | 476 |
| Human Swiss-Prot No. | P05023 |
| Species Reactivity | Human, Mouse, Rat |
| Cellular Localization | Basolateral cell membrane; Multi-pass membrane protein; Cell membrane (sarcolemma); Cell projection (axon); Melanosome (identified by mass spectrometry in melanosome fractions from stage I to stage IV) |
Background
The protein encoded by this gene belongs to the family of P-type cation transport ATPases, specifically the Na+/K+-ATPases. Na+/K+-ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na⁺ and K⁺ ions across the plasma membrane. These gradients are essential for osmoregulation, sodium-coupled transport of various molecules, and electrical excitability of nerve and muscle cells. The enzyme consists of two subunits: a large catalytic alpha subunit and a smaller glycoprotein beta subunit. The alpha subunit of Na+/K+-ATPase is encoded by multiple genes, and this gene encodes the alpha 1 isoform. Multiple transcript variants encoding different isoforms have been identified for this gene (RefSeq, May 2009).
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