ELK Biotechnology DDR1 (Phospho-Tyr513) Antibody
DDR1 (Phospho-Tyr513) 인산화 단백질을 인식하는 rabbit polyclonal 항체로, WB 및 ELISA에 적합합니다. 세포막 단백질 DDR1의 신호전달 연구 및 종양 관련 단백질 발현 분석에 활용됩니다. -20°C에서 1년 보관 가능합니다.
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DDR1 (Phospho-Tyr513) Antibody
제품 개요
DDR1 (Phospho-Tyr513) 항체는 인간 DDR1 단백질의 Tyr513 인산화 부위를 인식하는 rabbit polyclonal 항체입니다. 세포 신호전달, 성장, 분화 및 종양 연구에 유용합니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | DDR1 (Phospho-Tyr513) Antibody |
| Alternative Names | Epithelial discoidin domain-containing receptor 1, CD167 antigen-like family member A, Cell adhesion kinase, Discoidin receptor tyrosine kinase, HGK2, Mammary carcinoma kinase 10 (MCK-10), Protein-tyrosine kinase 3A (RTK-6), TRK E, Tyrosine kinase DDR, Tyrosine-protein kinase CAK, CD antigen CD167a |
| Applications | WB; ELISA |
| Recommended Dilutions | WB: 1:500–2000, ELISA: 1:10000–20000 |
| Immunogen | Synthesized phospho-peptide derived from human DDR1 (Phospho-Tyr513) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 130 kDa |
| Gene ID (Human) | 780 |
| Human Swiss-Prot No. | Q08345 |
| Species Reactivity | Human; Mouse; Rat |
| Cellular Localization | Isoform 1: Cell membrane (Single-pass type I membrane protein); Isoform 2: Cell membrane (Single-pass type I membrane protein); Isoform 3: Secreted; Isoform 4: Cell membrane (Single-pass type I membrane protein) |
Background
Receptor tyrosine kinases play a key role in cell communication with the microenvironment, regulating cell growth, differentiation, and metabolism. DDR1 belongs to a subfamily of tyrosine kinase receptors homologous to the Dictyostelium discoideum discoidin I protein in their extracellular domain and are activated by various types of collagen. Expression is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain, and is significantly overexpressed in several human tumors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene (RefSeq, Feb 2011).
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