ELK Biotechnology Smad1/5/9 rabbit pAb
Smad1/5/9 단백질을 인식하는 토끼 폴리클로날 항체로, WB 및 ELISA에 적합합니다. 인간, 마우스, 랫트 시료에 반응하며, 세포 내 BMP 신호전달 연구에 활용됩니다. -20°C에서 1년 보관 가능합니다.
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다ELK Biotechnology · ELK Biotechnology Smad1/5/9 rabbit pAb
제품 설명
ELK Biotechnology의 Smad1/5/9 rabbit pAb는 Smad1/5/9 단백질을 인식하는 토끼 유래 폴리클로날 항체입니다. 본 항체는 BMP 신호전달 경로 연구 및 관련 단백질 발현 분석에 유용합니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Smad1/5/9 rabbit pAb |
| Alternative Names | Mothers against decapentaplegic homolog 1/5/9 (MAD homolog 1), Mothers against DPP homolog 1, JV4-1, Mad-related protein 1, SMAD family member 1, SMAD 1/5/9, Smad1, hSMAD1, Transforming growth factor-beta-signaling protein 1, BSP-1 |
| Applications | WB; ELISA |
| Recommended Dilutions | WB 1:500–2000, ELISA 1:10000–20000 |
| Immunogen | Synthesized peptide derived from human Smad1/5/9 (AA range: 291–340) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 52 kD |
| Gene ID (Human) | 4086 / 4090 / 4093 |
| Human Swiss-Prot No | Q15797 / Q99717 / O15198 |
| Cellular Localization | Cytoplasm and nucleus. Cytoplasmic in the absence of ligand; translocates to the nucleus when complexed with SMAD4. Co-localizes with LEMD3 at the nuclear inner membrane. Exported from the nucleus to the cytoplasm when dephosphorylated. |
| Species Reactivity | Human; Mouse; Rat |
Background
The protein encoded by this gene belongs to the SMAD family, which is related to the Drosophila gene mothers against decapentaplegic (Mad) and the C. elegans gene Sma. SMAD proteins act as signal transducers and transcriptional modulators mediating multiple signaling pathways.
This protein mediates bone morphogenetic protein (BMP) signaling, which regulates cell growth, apoptosis, morphogenesis, development, and immune responses. Upon BMP ligand binding, it is phosphorylated by BMP receptor kinase and forms a complex with SMAD4 for transcriptional regulation. It is also a target for SMAD-specific E3 ubiquitin ligases (SMURF1, SMURF2), undergoing ubiquitination and proteasome-mediated degradation.
ELK Biotechnology 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.