ELK Biotechnology p53 (Acetyl-K305) rabbit pAb
인간 p53 단백질의 K305 아세틸화 부위를 인식하는 토끼 폴리클로날 항체. WB와 ELISA에 적합하며, 세포 내 p53의 위치 및 발현 연구에 유용. 고순도 IgG, 1 mg/ml 농도로 제공되며 -20°C에서 1년 보관 가능.
- 판매단위
- pk
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제품명
p53 (Acetyl-K305) rabbit pAb
대체 명칭
Cellular tumor antigen p53 (Antigen NY-CO-13), Phosphoprotein p53, Tumor suppressor p53
적용 분야
- Western Blot (WB)
- ELISA
권장 희석 배율
- WB: 1:1000
면역원 (Immunogen)
Synthesized acetyl peptide derived from human p53, amino acid range K305
보관 조건
- 종: Rabbit
- 온도: -20°C
- 유효기간: 1년
항체 정보
| 항목 | 내용 |
|---|---|
| Clonality | Polyclonal |
| Isotype | IgG |
| 농도 | 1 mg/ml |
| Gene ID (Human) | 7157 |
| Human Swiss-Prot No | P04637 |
| Species Reactivity | Human: K305 |
세포 내 위치 (Cellular Localization)
Cytoplasm, Nucleus, PML body, Endoplasmic reticulum, Mitochondrion matrix, Cytoskeleton (microtubule organizing center, centrosome).
Recruited into PML bodies with CHEK2 (PubMed:12810724).
Translocates to mitochondria upon oxidative stress or mitomycin C treatment (PubMed:22726440, 27323408).
- Isoform 1: Nucleus, Cytoplasm (predominantly nuclear, cytoplasmic with isoform 4)
- Isoform 2: Nucleus, minor cytoplasmic staining
- Isoform 3: Nucleus, cytoplasmic in some cells
- Isoform 4: Nucleus, translocates to cytoplasm
유전자 배경 (Background)
Tumor protein p53 (TP53) is a tumor suppressor in Homo sapiens. It contains transcriptional activation, DNA-binding, and oligomerization domains.
The protein responds to cellular stress by regulating target genes involved in cell cycle arrest, apoptosis, senescence, DNA repair, and metabolism.
Mutations are linked to various cancers, including hereditary Li-Fraumeni syndrome.
Alternative splicing and promoter usage generate multiple transcript variants and isoforms.
Additional isoforms may result from alternate translation initiation codons (PMIDs: 12032546, 20937277).
[Provided by RefSeq, Feb 2013]
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