ELK Biotechnology GLI-1 rabbit pAb

제품명

GLI-1 rabbit pAb

대체 이름

Zinc finger protein GLI1 (Glioma-associated oncogene) (Oncogene GLI)

적용 분야

• WB
• ELISA

권장 희석 배수

• WB: 1:500–2000
• ELISA: 1:10000–20000

면역원

Synthesized peptide derived from human GLI-1 (AA range: 460–490)

저장 조건

• -20°C / 1년 안정
• Rabbit

항체 특성

세포 내 위치

Cytoplasm, Nucleus.
Tethered in the cytoplasm by binding to SUFU (PubMed:10806483).
Activation and translocation to the nucleus is promoted by interaction with STK36 (PubMed:10806483).
Phosphorylation by ULK3 may promote nuclear localization (PubMed:19878745).
Translocation to the nucleus is promoted by interaction with ZIC1 (PubMed:11238441).
Isoform 2: Cytoplasm, Nucleus.

배경

This gene encodes a member of the Kruppel family of zinc finger proteins. The encoded transcription factor is activated by the sonic hedgehog signal transduction cascade and regulates stem cell proliferation. The activity and nuclear localization of this protein is negatively regulated by p53 in an inhibitory loop. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

종 반응성

Human, Mouse