ELK Biotechnology NAIP rabbit pAb
NAIP rabbit pAb는 인간 및 마우스 시료에 반응하는 다클론 항체로, IHC, IF, ELISA에 적합합니다. 세포질 및 신경 돌기 등에서 발현되는 NAIP 단백질 검출에 사용되며, 고순도 IgG 형태로 제공됩니다. 장기 보관이 가능하고 다양한 연구용으로 활용됩니다.
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제품명
NAIP rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | Baculoviral IAP repeat-containing protein 1 (Neuronal apoptosis inhibitory protein) |
| Applications | IHC; IF; ELISA |
| Recommended Dilutions | IHC-p 1:50–200, ELISA 1:10,000–20,000 |
| Immunogen | Synthetic peptide from human protein at AA range: 1191–1240 |
| Host Species | Rabbit |
| Storage Conditions | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Gene ID (Human) | 4671 |
| Human Swiss-Prot No. | Q13075 |
| Cellular Localization | Cytoplasm, basolateral plasma membrane, neuron projection, perikaryon, extracellular exosome |
| Species Reactivity | Human; Mouse |
Background
This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region.
This copy of the gene is full length; additional copies with truncations and internal deletions are also present in this region of chromosome 5q13.
It is thought that this gene is a modifier of spinal muscular atrophy caused by mutations in a neighboring gene, SMN1. The protein encoded by this gene contains regions of homology to two baculovirus inhibitor of apoptosis proteins, and it is able to suppress apoptosis induced by various signals. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
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