ELK Biotechnology Tubulin α rabbit pAb

제품명

Tubulin α rabbit pAb

제품 개요

Tubulin α 단백질은 세포골격의 미세소관(microtubule)을 구성하는 주요 단백질로, 세포 형태 유지 및 세포 내 수송에 중요한 역할을 합니다. 본 항체는 인간 Tubulin α 단백질의 특정 펩타이드 서열(AA 382-451)을 면역원으로 제작된 rabbit polyclonal antibody입니다.

제품 사양

Background

Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulins. The genes encoding these microtubule constituents belong to the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta, and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes, which are highly conserved among species. This gene encodes alpha tubulin and is highly similar to the mouse and rat Tuba1 genes. Northern blotting studies have shown that the gene expression is predominantly found in morphologically differentiated neurologic cells. This gene is one of three alpha-tubulin genes in a cluster on chromosome 12q.