ELK Biotechnology CD204 rabbit pAb
CD204 rabbit pAb는 인간, 마우스, 랫트에서 반응하는 다클론 항체로, IHC, IF, ELISA 등에 사용됩니다. 인간 MSR1 내부 영역 유래 펩타이드로 면역화되었으며, 세포막 단일 통과형 단백질을 표적합니다. -20°C에서 1년 보관 가능.
- 판매단위
- pk
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제품명
CD204 rabbit pAb
대체 명칭
Macrophage scavenger receptor types I and II
(Macrophage acetylated LDL receptor I and II; Scavenger receptor class A member 1; CD antigen CD204)
응용 분야
- IHC
- IF
- ELISA
권장 희석 배율
- IHC-p: 1:50–200
- ELISA: 1:10000–20000
면역원
The antiserum was produced against synthesized peptide derived from the internal region of human MSR1.
AA range: 241–290
저장 조건
- 종: Rabbit
- 온도: −20°C / 1년
항체 특성
| 항목 | 내용 |
|---|---|
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| GeneID (Human) | 4481 |
| Human Swiss-Prot No. | P21757 |
| Cellular localization | Membrane; Single-pass type II membrane protein |
| Species Reactivity | Human; Mouse; Rat |
배경 정보
This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer’s disease, and host defense.
The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low-density lipoproteins (LDLs).
The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis.
The isoform type 3 can inhibit the function of isoforms type 1 and 2.
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