ELK Biotechnology CD204 rabbit pAb
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| Product name: | CD204 rabbit pAb |
| Alternative Names: | Macrophage scavenger receptor types I and II (Macrophage acetylated LDL receptor I and II;Scavenger receptor class A member 1;CD antigen CD204) |
| Applications: | IHC;IF;ELISA |
| Recommended Dilutions: | IHC-p 1:50-200, ELISA 1:10000-20000 |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the Internal region of human MSR1. AA range:241-290 |
| Storage: | Rabbit |
| Storage: | -20°C/1 year |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Concentration: | 1 mg/ml |
| GeneID（Human）: | 4481 |
| Human Swiss-Prot No: | P21757 |
| Cellular localization: | Membrane; Single-pass type II membrane protein. |
| Background: | This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer`s disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type |
| Species Reactivity: | Human;Mouse;Rat |
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