ELK Biotechnology p53(Phospho-Ser366) rabbit pAb

제품명

p53(Phospho-Ser366) rabbit pAb

공급업체

ELK Biotechnology

제품 개요

이 항체는 인간 p53 단백질의 Ser366 인산화 부위를 인식하는 폴리클로날 토끼 항체입니다. 세포 스트레스 반응 및 암 억제 기전 연구에 유용합니다.

제품 스펙

세포 내 위치

Cytoplasm, Nucleus, PML body, Endoplasmic reticulum, Mitochondrion matrix, Cytoskeleton (microtubule organizing center, centrosome).
Recruited into PML bodies together with CHEK2 (PubMed:12810724).
Translocates to mitochondria upon oxidative stress (PubMed:22726440).
Translocates to mitochondria in response to mitomycin C treatment (PubMed:27323408).
Isoform-specific localization:

• Isoform 1: Predominantly nuclear; cytoplasmic when co-expressed with isoform 4
• Isoform 2: Mainly nuclear with minor cytoplasmic staining
• Isoform 3: Nuclear in most cells, cytoplasmic in some
• Isoform 4: Predominantly nuclear but translocates to cytoplasm

Background

Tumor protein p53 (TP53) in Homo sapiens encodes a tumor suppressor protein with transcriptional activation, DNA binding, and oligomerization domains.
This protein responds to diverse cellular stresses to regulate target gene expression, inducing cell cycle arrest, apoptosis, senescence, DNA repair, or metabolic changes.
Mutations in TP53 are associated with various human cancers, including hereditary Li-Fraumeni syndrome.
Alternative splicing and use of alternate promoters generate multiple transcript variants and isoforms.
Additional isoforms may result from alternate translation initiation codons (PMIDs: 12032546, 20937277).
[Provided by RefSeq, Feb 2013]