ELK Biotechnology Collagen IV rabbit pAb
Collagen IV 단백질을 인식하는 rabbit polyclonal antibody로, WB 및 ELISA에 적합합니다. Basement membrane 구성 단백질 검출에 유용하며, 인간, 마우스, 랫트 시료에 반응합니다. 고순도 IgG, -20°C에서 1년 보관 가능합니다.
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Collagen IV rabbit pAb
제품 개요
Collagen IV 단백질을 인식하는 rabbit polyclonal antibody입니다. Type IV collagen은 basement membrane의 주요 구성 성분으로, 세포외기질 연구 및 질환 관련 연구에 활용됩니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Collagen IV rabbit pAb |
| Alternative Names | collagen, type IV, alpha 1 |
| Applications | WB; ELISA |
| Recommended Dilutions | WB 1:500–2000, ELISA 1:10000–20000 |
| Immunogen | Synthesized peptide derived from Collagen IV (AA range: 1428–1443) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 130 kDa |
| Gene ID (Human) | 1282 |
| Human Swiss-Prot No. | P02462 |
| Cellular Localization | Secreted, extracellular space, extracellular matrix, basement membrane |
| Species Reactivity | Human; Mouse; Rat |
Background
This gene encodes a type IV collagen alpha protein, an integral component of basement membranes. It shares a bidirectional promoter with a paralogous gene on the opposite strand. The protein contains an amino-terminal 7S domain, a triple-helix collagenous domain, and a carboxy-terminal non-collagenous domain. It functions as a heterotrimer and interacts with extracellular matrix components such as perlecans, proteoglycans, and laminins. Proteolytic cleavage of the non-collagenous domain produces arresten, a biologically active fragment with anti-angiogenic and tumor suppressor properties. Mutations in this gene are associated with porencephaly, cerebrovascular disease, and renal and muscular defects. Alternative splicing results in multiple transcript variants.
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