ELK Biotechnology CD35 rabbit pAb
CD35 rabbit pAb는 인간, 쥐, 마우스에서 반응하는 다클론 항체로, WB 및 ELISA에 적합합니다. 보체 활성화 수용체 관련 단백질 검출에 사용되며, 높은 특이성과 안정성을 제공합니다. -20°C에서 1년간 보관 가능합니다.
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제품명
CD35 rabbit pAb
대체명
Complement component (3b/4b) receptor 1/2 (Knops blood group)
적용 분야
- WB
- ELISA
권장 희석 배수
- WB: 1:500–2000
- ELISA: 1:10000–20000
면역원
The antiserum was produced against synthesized peptide derived from the internal region of human CR1/CR1L.
AA range: 300–350 & 740–790
제품 정보
| 항목 | 내용 |
|---|---|
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 220 kD |
| GeneID (Human) | 1378 |
| Human Swiss-Prot No | P17927 / Q2VPA4 |
| Cellular Localization | Membrane; Single-pass type I membrane protein |
| Species Reactivity | Human, Rat, Mouse |
| Source | Rabbit |
| Storage | -20°C / 1 year |
배경 설명
This gene is a member of the receptors of complement activation (RCA) family and is located in the cluster RCA region of chromosome 1.
The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells.
The Knops blood group system is a system of antigens located on this protein.
The protein mediates cellular binding to particles and immune complexes that have activated complement.
Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus, and sarcoidosis.
Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variants are known.
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