Thermo Fisher Scientific Alpha Sarcoglycan Recombinant Rabbit Monoclonal Antibody (ARC2280)
Alpha Sarcoglycan 단백질을 인식하는 Thermo Fisher의 재조합 토끼 단클론 항체로, WB, IHC, ICC/IF, ELISA에 적합합니다. 높은 특이성과 재현성을 제공하며, 근육 조직 연구 및 사르코글리칸 복합체 분석에 유용합니다.
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Applications 및 Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:800 |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ARC2280 |
| Immunogen | A synthetic peptide corresponding to amino acids 288–387 of human alpha Sarcoglycan (SGCA) (Q16586) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2897900 |
Product Specific Information
- Positive Samples: Rat heart, Rat skeletal muscle
- Immunogen sequence:
VDALVTLLVP LLVALLLTLL LAYVMCCRRE GRLKRDLATS DIQMVHHCTI HGNTEELRQM AASREVPRPL STLPMFNVHT GERLPPRVDS AQVPLILDQH
Target Information
Sarcoglycan transmembrane proteins are members of the dystrophin complex. These proteins form a complex localized in the cell membrane of skeletal, cardiac, and smooth muscle fibers. The complex includes alpha-, beta-, gamma-, and delta-sarcoglycan subunits. Genetic defects in any of these proteins cause loss or reduction of the entire sarcoglycan complex, leading to autosomal recessive muscular dystrophy (sarcoglycanopathy). In smooth muscle, beta- and delta-sarcoglycans associate with epsilon-sarcoglycan, homologous to alpha-sarcoglycan. Complete deficiency in delta-sarcoglycan is linked to Syrian hamster BIO.14 cardiomyopathy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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