Thermo Fisher Scientific CEA Chimeric Recombinant Rabbit Monoclonal Antibody (EB-022)
CEA (CD66e) 특이적 항체로 인간 시료에 반응하며, WB, ICC/IF, ELISA에 사용 가능. 재조합 단클론 항체로 높은 특이성과 재현성을 제공. Protein A 정제, 액상 형태로 1 mg/mL 농도. 연구용으로만 사용.
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Thermo Fisher Scientific CEA Chimeric Recombinant Rabbit Monoclonal Antibody (EB-022)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunocytochemistry (ICC/IF) | 1:1,000 |
| ELISA | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | EB-022 |
| Immunogen | This antibody was generated by immunising BALB/c mice. Splenocytes from immunised mice were obtained and fused with myeloma cells to generate a hybridoma. Target antigen: CD66e (CEACAM5, UniProt ID: P06731-1, antigen range 1–702). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
Product Specific Information
EB-022 was shown by ELISA to react specifically with CEA (CD66e), as opposed to the related CD66 family member CD66c.
Target Information
CEA (Carcino Embryonic Antigen, CD66e) is synthesized during development in the fetal gut and re-expressed in increased amounts in intestinal carcinomas and several other tumors.
CEA is a member of the carcinoembryonic antigen family and immunoglobulin supergene family, consisting of one N domain and six immunoglobulin constant-like A and B domains.
Antibodies to CEA are useful in identifying the origin of various metastatic adenocarcinomas and distinguishing pulmonary adenocarcinomas (CEA+) from pleural mesotheliomas (rarely CEA+).
CEA serves as a tumor marker for adenocarcinoma and is found in digestive system epithelium and fetal colon.
The CEA family includes cell adhesion molecules and pregnancy-specific glycoproteins located on chromosome 19.
CEA mediates cell adhesion and participates in differentiation, tissue structure, angiogenesis, apoptosis, tumor suppression, metastasis, and immune modulation.
Multiple transcript variants encoding different isoforms have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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